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The adverse reactions due to single oral doses of nomifensine (NOM) 50 mg and maprotiline (MAP) 50 mg were compared in 10 healthy young (22 to 24 yrs of age, average 22.1 yrs) male volunteers in double-blind, corss-over fashion. Including self-rating, some physiological and psychological measurements were applied before and at times through 24 hrs after the administrations.<BR>The numbers who complained of adverse reactions were almost equal in both drugs, but severity of drowsiness and physical tiredness was significantly higher in the cases of MAP administration than in those of NOM administration. Pulse rate increased by 3.4% to 19.8% after NOM administration, but decreased slightly 2 to 3 hrs after the administration of MAP and significant difference was detected between the two drugs (P<0.05). No significant difference was observed on the blood pressure between both drugs. NOM did not decrease critical fusion frequency of flicker. On the other hand, MAP decreased it by 7.6% 6 hrs after the administration and significant difference was observed at 4, 5, 6 and 8 hrs after the drugs (P<0.01). Regarding the influence on salivary rate, NOM did not change the rate, but MAP decreased it severely (morethan 50% of before drug level) and significant difference was observed between the two drugs from 4 to 8 hrs after the administration (P<0.01). There was no difference between the two drugs on the function equilibrium, simple reaction time and correct response in immediate memory test.<BR>In conclusion, these results suggest that NOM 50 mg lacks the sedative effect and the depressing effect on salivation in normal young volunteers, while MAP 50 mg showed these effects markedly. The difference between the two drugs on these effects was prominent.
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