Changes in the Serum Enzyme Levels and the Predicting Factors during 2 Weeks Hospitalization in Healthy Male Volunteers: A Retrospective Study. Changes in Serum Levels of GOT,GPT,.GAMMA.-GTP,LDH,ALP and LAP.:Changes in Serum Levels of GOT, GPT, γ-GTP, LDH

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The change in the serum enzyme activities was studied during a 2-week hospitalization period in 93 healthy young (ages 20 to 29 years) male volunteers. 1) Activities of GOT, GPT, γ-GTP and LAP were significantly elevated during the long-term hospitalization, while LDH and ALP were transiently reduced. In eight volunteers the GPT level was increased to more than the upper normal value and the γ-GTP level likewise increased in one. 2) The data of subjects who gained over 1 kg during hospitalization resulted in a signifi cant elevation in GOT and a tendency toward GPT elevation. 3) No clear parameter was obtained predicting a change in serum GPT activity from the data prior to the long-term hospitalization. However, the following factors related to the predictive parameters of GPT elevation might be considered: (1) Obesity before hospitalization is less than 100%. (2) GOT/GPT ratio is over 3 combined with a low GPT level before hospitalization. (3) Low level of LAP prior to hospitalization (4) No weight gain after hospitalization