Acute and Chronic Effects of Nitroglycerin Tape on Metabolic Response during Exercise in Patients with Angina Pectoris.

概要

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A multicenter study was undertaken to evaluate the efficacy of nitroglycerin tape (NTG tape; 5 mg/sheet) on the exercise capacity in patients with angina pectoris. Aftertwo control cardiopulmonary exercise tests, 12 patients received a strip of NTG tapeevery 12 hours for 4 weeks. The exercise tests were repeated 3 hours after the firstapplication of NTG tape and after the 28th day to evaluate the acute and chronic effects, respectively. Using a treadmill, the ramp protocol was employed for the exercise test.Exercise time (Ex-Time: sec), peak oxygen uptake (peak VO2), and the anaerobicthreshold (AT) and exercise time to AT determined by respiratory gas analysis weremeasured. Results were as follows: 1) Exercise time was prolonged significantly in the acute (p <0.05) and chronic (p <0.05) study. 2) Peak VO2 was significantly increasedonly in the acute study (p <0.05). 3) In the acute study, exercise time to AT tended toincrease (p <0.05). In the chronic study, AT (p <0.01) and exercise time to AT (p <0.01) demonstrated further improvement. 4) Two patients who demonstrated an increase inexercise time in the acute study did not demonstrate an increase in the chronic study. It was suggested that NTG tape improves not only myocardial ischemia, but also themetabolic response to submaximal exercise in patients with angina pectoris, whiletolerance to nitroglycerin may develop in some cases at three hours after applicationwith chronic use.