低体温法下の副腎皮質機能に関する基礎的研究--ウシ副腎皮質培養細胞におけるコルチコイド産生に対する低温の影響

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Effects of hypothermia on corticoidogenesis (CG) were investigated in primary cultured bovine adrenocortical cells. In order to evoke CG, adrenocorticotropic hormone (ACTH), dibutyryl cyclic AMP (db-cAMP), and high K+ were used. In the presence of the above mentioned secretagogues, cells were incubated at 37°C, 27°C, and 20°C for 1 hour. Although there was no difference between the ACTH-induced CGs at 37°C and 27°C, CG was significantly lower at 20°C. Both db-cAMP and high K+-induced CGs were significantly lower at 27°C, and were not observed at 20°C.These results indicate that CG is not affected by moderate hypothermia, and is not eliminated even by deep hypothermia. It is also suggested that ACTH influences not only adenylate cyclase and Ca2+ channels, but also various processes of glucocorticoid production and could evoke CG at 20°C in bovine adrenocortical cells.
一般社団法人日本温泉気候物理医学会の論文