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Effect of oxatomide on contraction of canine bronchial smooth muscle caused by administration of histamine and by challenge of ascaris-antigen were investigated and compared against the effects of histamine H<SUB>1</SUB>-receptor antagonist (CPM) and inhibitor of histamine release from mast cells (DSCG).<BR>Oxatomide in concentrations of 0.05μg/ml to 2.0μg/ml inhibited, dose-respon-sively, contraction of bronchial smooth muscle strip by administration of histamine (10μg/ml). When this concentration was less than 0.3μg/ml, CPM inhibited the contraction significantly stronger than oxatomide. However, in concentration over 0.5μg/ml, no difference in inhibitory effect could be demonstrated. On the other hand, DSCG could not inhibit the contraction. Oxatomide in concentrations of 0.05μg/ml to 1.0μg/ml inhibited, dose-responsively, contraction of the muscle strip sensitized spontaneously by ascaris antigen challengs. There was no difference in inhibitory effect between oxatomide and DSCG at the same level of concentration. Oxatomide (0.5μg/ml) and CPM (0.5μg/ml) both inhibited completely the constriction response of bronchus caused by histamine stimulation (10μg/ml). Although constriction response by ascaris antigen challenge was inhibited completely by oxatomide (0.5μg/ml), it could not be inhibited completely by CPM (0.5μg/ml). Oxatomide inhibited even the residual constriction response which could not accomplished by CPM.<BR>These results suggest that oxatomide might have not only an effect as a histamine H<SUB>1</SUB>-receptor antagonist and anti-histamine releasing agent from mast cell, but also anti-SRS-A.
著者
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向井 勝紀
広島大学医学部第2外科
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高杉 純好
広島大学医学部第2外科
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上田 敏明
広島大学医学部第二外科学教室
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米原 修治
広島大学医学部第二生理学教室
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向井 勝紀
広島大学医学部第二外科学教室
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藤井 一元
広島大学医学部第二生理学教室
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藤井 一元
広島大学医学部第2生理学教室
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