EFFECT OF DOMPERIDONE ON GASTRIC MOVEMENT AND BLOOD FLOW IN DOG
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The influence of intravenous administration of domperidone on the gastric movement and venous blood flow were investigated. Dogs were anesthetized with nembutal and also immobilized with gallamine triethioid. The following results were obtained.<BR>(1) Augmentation of the gastric movement by domperidone involved an amplification of contraction only and was rarely accompanied by a rise in tone or change of contraction rate.(2) Excitatory response of gastric movement caused by administration of domperidone in splanchnicotomized dog returned to their original movement by bilateral vagotomy.(3) Domperidone augmented the gastric movement in dog of which vagal and splachnic nerves had been severed. Such a excitatory response of gastric movement by domperidone was diminished by administration of TTX or atropine.(4) Domperidone inhibited the gastric motor inhibitory response in the vago-vagal relex.(5) Discharges from gastric motor excitatory point in the medulla oblongata were increased by domperidone, whereas, decrease in response of frequency of discharges from gastric motor excitatory point caused by vago-vagal gastric motor inhibitory reflex was inhibited by domperidone.(6) Stimulation effect at the gastric motor excitatory point in the medulla oblongata was augmented by domperidone.(7) Gastric movement was inhibited by administration of high dose domperidone. These results suggest that domperidone stimulates the cholinergic gastric motor excitatory neurons in the medulla oblongata, on the one hand, and stimulates the gastric motor excitatory neurons in the intramural plexus on the other.(8) Gastric venous blood flow was augmented by domperidone which continued as long as the gastric motor excitatory response persisted.
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