EFFECTS OF METOCLOPRAMIDE ON THE ISOLATED GUINEA-PIG INTESTINE

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Effects of Metoclopramide on the isolated intestine of guinea-pig were studied. The results obtained were as follows: 1) Metoclopramide usually produced a stimulating action on each preparation of the isolated jejunum, ileum and colon of guinea-pig. 2) Maximum tension was observed at the concentrations of Metoclopramide (10-5-10-4 g/ml) on the isolated guinea-pig colon. 3) The stimulating action of Metoclopramide was not observed on KCl-depolarized preparation of the isolated guinea-pig colon. 4) Atropine (10-5 g/ml) did not block the stimulating action of Metoclopramide on the isolated guinea-pig colon. 5) The stimulating action of Metoclopramide on the isolated guinea-pig colon was blocked by hexamethonium (2.5±10-3 g/ml), tetrodotoxin (10-6g/ml) and the treatment of botulinum toxin (type C, 105 mouse LD50/ml, 15 min.). 6) High concentration of Metoclopramide (1.5±10-4 g/ml) blocked the nicotine contraction. From these results, it was suggested that Metoclopramide had a stimulating action on the isolated intestine of guinea-pig not through the muscle membrane, but through the intrinsic nerve. Furthermore, it would be considered that high concentration of Metoclopramide had an inhibitory action.
日本平滑筋学会の論文