チアミン関連物質のマススペクトル

概要

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Fragmentations of16derivatives related to thiamine were examined with the aid of high-resolution mass spectrometry, deuterium exchange and model compounds. The amine salts decomposed thermally to the free bases(M)whereas thiamine homologues gave M-H ions(a)lost the4'NH hydrogen. Further fragmentation from the ions(a)gave(a-SH)ions and 2-methylpyrimido[4, 5-d]pyrimidine. The CN bond of methylene bridge in thiamine homologues cleaves easily to form pyrimidylmethyl moieties, chloromethylpyrimidines and the other rings such as thiazole, thiothiazolone, imidazole, pyrazole, quinoline and pyridine. The base peak of thiazolium derivatives were due to the thiazole portion whereas those of tertiary amines examined were owing to the pyrimidines. Fragments of the pyrimidines undergo successive elimination of CH3CN, HCN or NH2CN. Fragmentations of the thiazole moieties and the model compounds(I, II)were interpreted that the substituents(CH3, CH2 OH), HCN, and CH, CN were eliminated successively to form fragments such as C4H5S, C3H3S, CH3CS, HCS, etc.
日本質量分析学会の論文