インフルエンザの流行におけるワクチン効果に関する研究

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For the prevention of influenza, immunization through vaccination appears to be the only method presently available. Following the Asian innfluenza (A2 type) epidemic in 1957, a new epidemic of influenza caused by a new type A virus (Hong Kong type) with special antigenic structure unlike the previous A2 type broke out here in July 1968. During this outbreak of Hong Kong influenza, the authors selected an area which had not been invaded by the first wave and inoculated a population with a vaccine containing A2 Hong Kong virus strain and a control group with a placebo to await the arrival of the Hong Kong influenza, During the second wave of the epidemic of Hong Kong influenza in this country, the same infection appeared in this area, so that it became possible to study the effect of the vaccine from the viewpoint of incidence and serological responses. The following results were obtained. The epidemic of Hong Kong influenza was seen in this area from December 1969 to January 1970. This corresponded to one after vaccine inoculation. The maximum effect of the vaccine was expected to be obtained around this time . In view of the rather short duration of the immunicty after inoculation of this vaccine, it is dangerous to assume an overall effect based on these values. However, the frequency of appearance of symptoms of a common cold was significantly higher in the controls than in the inoculated group. Influenza-like illness occurred 4 times more frequently in the controls than in the inoculated group, definitely indicating a protective effect of the present vaccine. Based on these facts, the present commercial vaccine appears to be of some significant preventive value if sufficient time elapses between vaccination and subsequent exposure to offending viruses. However, the effect of the present commercial vaccine appears to last only 3-4 months after inoculation. In the use of present vaccine, another inoculation towards the end of December or the beginning of January as a 3rd additional immunization is recommended, in order to prevent an epidemic from arising during November to May.
日本民族衛生学会の論文

インフルエンザの流行におけるワクチン効果に関する研究

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