Solution equilibria of histidine-containing ternary amino acid-Copper(II) complexes in 20v/v% dioxane-water.
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概要
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Equilibria of histidine-containing ternary amino acid–copper(II) systems have been investigated by potentiometric titration in acid–neutral solution in 20 v/v% dioxane–water containing 0.1 M KNO<SUB>3</SUB> (1 M=1 mol dm<SUP>−3</SUP>) at 25 °C. The stability constants of the binary complexes of histidine (his) and other amino acids (A) with a polar or a nonpolar side chain (A: serine, threonine, homoserine, asparagine, glutamine, citrulline, glycine, alanine, or valine) and the ternary complexes Cu(his)(A) have been calculated by the method of nonlinear least-squares. The overall stability constants for CuA, CuA<SUB>2</SUB>, and Cu(his)(A) are higher than the values reported for the corresponding complexes in water, those for Cu(his) and Cu(his)<SUB>2</SUB> remaining unaffected. The stability constants (logβ<SUB>1110</SUB>) for Cu(his)(A) are in the range 17.4–18.0, no difference in stability being observed between the diastereomers Cu(L-his)(L-A) and Cu(D-his)(L-A). Species distribution as a function of pH reveals that Cu(his)(A) predominates in the neutral region. The stability constants have been compared with various theoretical values and found to be higher than the statistically estimated ones.
- 公益社団法人 日本化学会の論文
著者
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Yamauchi Osamu
Faculty Of Engineering Kansai University
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Sakurai Takeshi
Institute For Molecular Science
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Yamauchi Osamu
Faculty of Pharmaceutical Sciences, Osaka University
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Takaba Toshikazu
Faculty of Pharmaceutical Sciences, Osaka University
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