Reactions of .ALPHA.-aminoacetonitriles with isothiocyanates. Synthesis of 1,3-disubstituted 5-imino-2-thiohydantoins.

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概要

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• The reactions of α-aminoacetonitriles with isothiocyanates gave 1-cyanomethyl-1,3-disubstituted thioureas or 1,3-disubstituted 4-amino-4-imidazoline-2-thiones depending upon the reaction conditions. In the presence of polar organic solvents such as methanol the former products were easily cyclized to the latter. 1,3-Disubstituted 4-amino-4-imidazoline-2-thiones were autoxidized in methanol affording 1,3-disubstituted 5-imino-2-thiohydantoins.

• 公益社団法人 日本化学会の論文

著者

• Tamura Chihiro

  Central Research Laboratories Sankyo Co., Ltd.

• Kinoshita Takeshi

  Central Research Laboratories, Sankyo Co., Ltd.

• Watanabe Hiroko

  Central Research Laboratories, Sankyo Co., Ltd.

• Sato Sadao

  Central Research Laboratories, Sankyo Co., Ltd.

関連論文

• Studies on 1,2,4-thiadiazolidine derivatives. I. The synthesis and structural determination of 2,4-disubstituted 3,5-disubstituted imino-1,2,4-thiadiazolidines.
• Studies on 1,2,4-thiadiazolidine derivatives. IV. The isomers of 2,4-disubstituted 3,5-(disubstituted imino)-1,2,4-thiadiazolidines.
• The Crystal Structure of Pyrazinic Acid
• Reactions of .ALPHA.-aminoacetonitriles with isothiocyanates. Synthesis of 1,3-disubstituted 5-imino-2-thiohydantoins.
• Studies on 1-(thiosulfinylaminothio)piperidines.
• The synthesis of anthglutin and its analogues.

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