The synthesis of anthglutin and its analogues.

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概要

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• Anthglutin (1-γ-L-glutamyl-2-(2-carboxyphenyl)hydrazine) and its analogues were synthesized. Their inhibitory activity on γ-glutamyl transpeptidase was measured. 2-Carboxyphenyl derivatives, including anthglutin, showed inhibitory activity, while the other derivatives did not. The 2-carboxyl group seems to be essential for the inhibitory activity.

• 公益社団法人 日本化学会の論文

著者

• Kinoshita Takeshi

  Central Research Laboratories, Sankyo Co., Ltd.

• Watanabe Hiroko

  Central Research Laboratories, Sankyo Co., Ltd.

• Minato Sadamasa

  Fermentation Research Laboratories, Sankyo Co., Ltd.

関連論文

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• Reactions of .ALPHA.-aminoacetonitriles with isothiocyanates. Synthesis of 1,3-disubstituted 5-imino-2-thiohydantoins.
• The synthesis of anthglutin and its analogues.

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