Synthesis and properties of O6-substituted guanosine derivatives.
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概要
- 論文の詳細を見る
Reactions of 2′,3′,5′-tri-<I>O</I>-acetyl-<I>N</I><SUP>2</SUP>-protected or unprotected guanosine derivatives with phosphoryl, phosphinothioyl, arylsulfonyl, and silyl halides in dichloromethane gave the corresponding <I>O</I><SUP>6</SUP>-substituted guanosine derivatives in good yields. In these reactions, 4-(dimethylamino)pyridine (DMAP) was found to be very effective catalyst. The physical data of these products and their stabilities under acidic and basic conditions were described in detail. Selective detritylation of <I>O</I><SUP>6</SUP>-arylsulfonyl-<I>N</I><SUP>2</SUP>-tritylguanosine derivatives was accomplished by treatment with 80% acetic acid. It was found that <I>O</I><SUP>6</SUP>-dibutylphosphinothioyl derivatives were relatively stable under conditions where acetyl group was predominantly removed.
- 公益社団法人 日本化学会の論文
著者
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Sekine Mitsuo
Department Of Life Chemistry Tokyo Institute Of Technology
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Hata Tsujiaki
Department of Chemistry Tokyo Institute of Technology
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Daskalov Hristo
Department of Life Chemistry, Tokyo Institute of Technology
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