Synthesis and properties of S,S-diaryl thymidine phosphorodithioates.
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概要
- 論文の詳細を見る
Appropriately protected or unprotected <I>S</I>,<I>S</I>-diphenyl thymidine 3′- or 5′-phosphorodithioates and <I>S</I>,<I>S</I>-bis(4-methoxyphenyl) thymidine 3′- or 5′-phosphorodithioates were successfully prepared by the reaction of the thymidine derivatives with cyclohexylammonium <I>S</I>,<I>S</I>-diaryl phosphorodithioates in the presence of 2,4,6-triisopropylbenzene-sulfonyl chloride (TPS). Stabilities of the thymidylic compounds under acidic or alkaline conditions were described in detail. Several methods for the deprotection of one or both arylthio groups under neutral conditions were also described in connection with the synthesis of oligothymidylates. By the use of the bis(4-methoxyphenylthio)phosphoryl group, di- and tri-thymidylates were synthesized in high yields.
- 公益社団法人 日本化学会の論文
著者
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Sekine Mitsuo
Department Of Life Chemistry Tokyo Institute Of Technology
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Hata Tsujiaki
Department of Chemistry Tokyo Institute of Technology
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Hamaoki Ken
Department of Life Chemistry, Tokyo Institute of Technology
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