A new efficient and stereoselective synthesis of ubiquinone-10.
スポンサーリンク
概要
- 論文の詳細を見る
Coupling reaction of 6-cupro-2,3-dimethoxy-5-methylhydroquinone bis(2-methoxyethoxymethyl) ether with (2<I>E</I>)-1-(phenylsulfonyl)-2-methyl-4-chloro-2-butene afforded the sulfone-functionalized prenylhydro quinone (<B>6</B>) in 82% yield. Stereoselective synthesis of ubiquinone-10 was achieved by the condensation of <B>6</B> and solanesyl bromide (yield 92%), reductive elimination of the sulfone group by sodium–ethyl alcohol in THF (yield 80%), and followed by air oxidation of the hydroquinone.
- 公益社団法人 日本化学会の論文
著者
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FUJITA YOSHIJI
Central Research Laboratories, Kuraray Co. Ltd.
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Fujita Yoshiji
Central Research Laboratories Kuraray Co. Ltd.
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Nishida Takashi
Central Research Laboratories, Kuraray Co. Ltd.
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Ishiguro Michihiro
Central Research Laboratories, Kuraray Co. Ltd.
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Onishi Takashi
Central Research Laboratories, Kuraray Co. Ltd.
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