Preferential introduction of a pyridylmethyl group into sulfonamides as an approach to an intramolular transimination.
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概要
- 論文の詳細を見る
<I>N</I>,<I>N</I>′-Bis(<I>p</I>-tolylsulfonyl)-α-ω-alkanediamine disodium salts (<I>n</I>=3, 4, 5, 6, 7, 8, 9, 10) were subjected to monopyridylmethylation by the reaction with 5′-deoxy-5′-chloro- or 5′-deoxy-2′-chloro-3,4′-<I>O</I>-isopropylidenepyridoxine hydrochloride, accompanied by the corresponding bispyridylmethylation. Monopyridylmethylation became remarkable for longer methylene chains of the diamine. Thus, introduction of an amino group protected by a sulfonyl group at the end of either the C<SUB>2</SUB>- or the C<SUB>5</SUB>-side chains of pyridoxine derivatives was achieved.
- 公益社団法人 日本化学会の論文
著者
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IWATA Masaaki
The Institute of Physical and Chemical Research
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Kuzuhara Hiroyoshi
The Institute of Physical and Chemical Research
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