Bronsted relation for hydrogen.RAR.deuterium exchange reactions of imidazole-bearing molecules with amino groups.
スポンサーリンク
概要
- 論文の詳細を見る
The base-catalyzed hydrogen→deuterium exchange rates of the imidazole C-2 protons were measured for the imidazole-bearing molecules with amino groups (N<SUP>2</SUP>H<SUB>2</SUB>·Im) in <SUP>2</SUP>H<SUB>2</SUB>O at various pH. From the pH dependences of the pseudo-first-order rate constants, the second-order rate constants were obtained for the N<SUP>2</SUP>H<SUB>3</SUB><SUP>+</SUP>·Im<SUP>2</SUP>H<SUP>+</SUP> species and for the equilibrium mixtures of the N<SUP>2</SUP>H<SUB>2</SUB>·Im<SUP>2</SUP>H<SUP>+</SUP> and N<SUP>2</SUP>H<SUB>3</SUB><SUP>+</SUP>·Im species. For both the N<SUP>2</SUP>H<SUB>3</SUB><SUP>+</SUP>·Im<SUP>2</SUP>H<SUP>+</SUP> and N<SUP>2</SUP>H<SUB>2</SUB>·Im<SUP>2</SUP>H<SUP>+</SUP> species, the second-order rate constants and microscopic dissociation constants of the imidazolium rings were found to satisfy the Brφnsted relation, with concomitant estimation of the abundance ratio of the N<SUP>2</SUP>H<SUB>2</SUB>·Im<SUP>2</SUP>H<SUP>+</SUP> and N<SUP>2</SUP>H<SUB>3</SUB><SUP>+</SUP>·Im species. This abundance ratio was compared with that estimated from the pH dependence of proton chemical shifts.
- 公益社団法人 日本化学会の論文
著者
-
SHIMADA Ichio
Department of Chemistry, Faculty of Science, Konan University
-
Inagaki Fuyuhiko
Department Of Molecular Physiology The Tokyo Metropolitan Institute Of Medical Science
-
Miyazawa Tatsuo
Department Of Biophysics And Biochemistry Faculty Of Science The University Of Tokyo
-
Endo Toshiya
Department of Biophysics and Biochemistry, Faculty of Science, The University of Tokyo
-
Shimada Ichio
Department of Biophysics and Biochemistry, Faculty of Science, The University of Tokyo
-
Inagaki Fuyuhiko
Department of Biophysics and Biochemistry, Faculty of Science, The University of Tokyo
関連論文
- Three-dimensional Solution Structure of Calcium Channel Activator : Impreratoxin A Determined by NMR Spectroscopy
- 汽水棲環形動物の酸性スフィンゴ糖脂質:イトメ(Tylorrhynchus heterochetus)の2種類新型イノシトールリン酸糖脂質の構造解析
- Clusters of Basic Amino Acids in Midkine: Roles in Neurite-Promoting Activity and Plasminogen Activator-Enhancing Activity^1
- NMR Structure of the Heterodimer of Bem1 and Cdc24 PB1 Domains from Saccharomyces Cerevisiae
- Effects of Double Mutation at Two Distant IgE-binding Sites in the Three-dimensional Structure of the Major House Dust Mite Allergen Der f 2 on IgE-binding and Histamine-releasing Activity(Biochemistry & Molecular Biology)
- Solution Structure of the SH2 Domain of Grb2 / Ash Complexed with EGF Receptor-Derived Phosphotyrosine-Containing Peptide
- A Role of Cofilin/Destrin in Reorganization of Actin Cytoskeleton in Response to Stresses and Cell Stimuli
- Identification of the Receptor-Recognition Site of Bombyxin-II, A Silkmoth Insulin-Like Peptide
- Ligand-Binding Enhances the Affinity of Dimerization of the Extracellular Domain of the Epidermal Growth Factor Receptor
- ミミズ(Pheretima sp.)における非還元末端にグルコ-スを有する新型のNeogala系スフィンゴ糖脂質
- 2P-133 ミトコンドリアマトリクスのインポートモータmtHsp70の作動機構の解析(分子モーター,第47回日本生物物理学会年会)
- Solution Structure of Cysteine-Rich Domain of Protein Kinase C_α^1
- INTERACTION OF WASP VENOM PEPTIDE, MASTOPARAN, WITH PHOSPHOLIPID MEMBRANE; : BIOLOGICAL ACTIVITY AND DYNAMIC STRUCTURE OF MEMBRANE-BOUND STATE
- CLc3 A NOVEL LYSINE-SUBSTITUTED NUCLEOSIDE IN THE FIRST POSITION OF THE ANTICODON OF MINOR ISOLEUCINE tRNA FROM Escherichia coli
- 3P-030 ミトコンドリア膜間部タンパク質Tim40の構造解析(蛋白質-構造機能相関,第47回日本生物物理学会年会)
- Avidin Fusion Protein as a Tool to Generate a Stable Translocation Intermediate Spanning the Mitochondrial Membranes^1
- Arabidopsis thaliana Has a Set of J Proteins in the Endoplasmic Reticulum that are Conserved from Yeast to Animals and Plants
- Cephalometric evaluation of anterior open-bite nonextraction treatment, using multiloop edgewise archwire therapy
- NMR lanthanoid-probe analyses of conformational properties of 8,2'-S-cycloadenosine 3'-monophosphate in aqueous solution.
- Potent novel mutagens produced by broiling fish under normal conditions.
- Bronsted relation for hydrogen.RAR.deuterium exchange reactions of imidazole-bearing molecules with amino groups.
- Chemical Equilibria between a Lanthanide Shift Reagent and n-Hexylamine in Chloroform
- Lanthanide-Induced Nuclear Magnetic Resonance Shifts and Molecular Structure of L-Azetidine-2-Carboxylic Acid. II. Determination of Molecular Conformation
- Lanthanide-Induced Nuclear Magnetic Resonance Shifts and Molecular Structure of L-Azetidine-2-Carboxylic Acid. I. Evaluation of the Shifts Intrinsic to the Lanthanide-Substrate 1:1 Complex
- Vibrational spectra and rotational isomerism of alkyl vinyl ethers.
- Metal(II)-Ion Promoted Hydrolysis of Glycylglycine
- Infrared and Raman Spectra and Rotational Isomerism of 1,4-Pentadiene
- Solution Structure of the SH2 Domain of Grb2/Ash Complexed with EGF Receptor-Derived Phosphotyrosine-Containing Peptide.
- Clusters of Basic Amino Acids in Midkine: Roles in Neurite-Promoting Activity and Plasminogen Activator-Enhancing Activity.