Optically active cyclic dipeptide carrying 9-anthryl groups.
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概要
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Optically active 3-(9-anthryl)alanine was synthesized for the first time and its cyclic dipeptide, cyclo(D-9-anthrylalanine)<SUB>2</SUB>, was prepared. Conformation of the cyclic dipeptide in solution was investigated by means of <SUP>1</SUP>H NMR, absorption, circular dichroism (CD), and fluorescence spectroscopy. The coupling parameter <I>J</I><SUB>NH-C<SUP>α</SUP>H</SUB>, observed in the NMR spectra indicated a planar configuration for the 2,5-piperazinedione ring of the dipeptide. The cyclic dipeptide showed a moderately large exciton couplet in CD spectrum and a small splitting in the <SUP>1</SUP>B<SUB>b</SUB> absorption band, but no excimer emission in fluorescence spectrum. These spectroscopic data suggest an unfolded-unfolded conformation for the side chains of the cyclic dipeptide.
- 公益社団法人 日本化学会の論文
著者
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Imanishi Yukio
Department Of Material Chemistry Graduate School Of Engineering Kyoto Univeresity
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Egusa Syun
Department of Polymer Chemistry, Faculty of Engineering, Kyoto University
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Sisido Masahiko
Research Center for Medical Polymers and Biomaterials, Kyoto University
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