Palladium-catalyzed reaction of 2-vinyl-2,3-dihydrobenzofurans and chroman with nucleophiles.
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概要
- 論文の詳細を見る
Reaction of 2,3-dihydro-2-vinylbenzofuran with nucleophiles (NaCH(COOEt)<SUB>2</SUB> and PhNHCH<SUB>3</SUB>) in the presence of palladium catalysts such as Pd(PPh<SUB>3</SUB>)<SUB>4</SUB> and PdCl<SUB>2</SUB>(PR<SUB>3</SUB>)<SUB>2</SUB> (R=Ph and Et) gives 2-(2-butenyl)phenols (46–76% yields) in which nucleophiles are incorporated into the methyl group of the butenyl moiety. 2-Vinylchroman undergoes the same type of reaction where only the palladium complex bearing PEt<SUB>3</SUB> ligand is effective. The effectiveness of PEt<SUB>3</SUB> ligand is also observed in the reaction of 2,3-dihydro-2-isopropenylbenzofuran with diethyl sodiomalonate leading to 3-ethoxycarbonyl-4-(2-methyl-1-propenyl)-2-chromanone.
- 公益社団法人 日本化学会の論文
著者
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Hosokawa Takahiro
Department Of Biology Faculty Of Science Kobe University
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Murahashi Shun-ichi
Department Of Applied Chemistry Okayama University Of Science
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Uno Toru
Department of Chemistry, Faculty of Engineering Science, Osaka University
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Kono Takanori
Department of Chemistry, Faculty of Engineering Science, Osaka University
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