Reaction of rifamycins with sodium sulfinates.

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概要

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• The reaction of rifamycin S and the quinonic 3-(hydrazonomethyl)rifamycin derivatives with sodium sulfinates under neutral conditions were found to afford the hydroquinone-type 4-<I>O</I>-sulfonyl derivatives of rifamycin. 3-Amino-4-deoxo-4-iminorifamycin S also gave rise to the hydroquinone-type 4-deoxy-4-sulfonylamino derivatives of rifamycin when treated with sodium sulfinates. Under acidic conditions, rifamycin S and 3-bromorifamycin S produced the hydroquinone- and quinone-type 3-sulfonyl derivatives of rifamycin, respectively, by reactions with sodium sulfinates. Some of sodium salts of 4-<I>O</I>-sulfonylrifamycin SV derivatives afforded rifamycin S and sodium sulfinates and/or sodium sulfonates when heated in AcOEt.

• 公益社団法人 日本化学会の論文

著者

• Tsukamoto Goro

  Pharmaceuticals Research Center Kanebo Ltd.

• Taguchi Masahiro

  Pharmaceuticals Research Center, Kanebo, Ltd.

• Aikawa Norio

  Pharmaceuticals Research Center, Kanebo, Ltd.

• Yoshida Kenzaburo

  Pharmaceuticals Research Center, Kanebo, Ltd.

• Kitamura Mikiya

  Pharmaceuticals Research Center, Kanebo, Ltd.

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• Reaction of rifamycins with sodium sulfinates.
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