Footprint catalysis. III. Inducible alteration of substrate specificities of silica(alumina) gel catalysts for 2,4-dinitrophenolysis of toluic anhydrides by footprint imprinting.
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概要
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A tailor-made catalyst design was attempted for a required substrate specificity by the authors' footprint imprinting method. Two silica(alumina) footprint catalysts were prepared by imprinting with <I>N</I>-benzoylbenzenesulfonamide (<B>1</B>) and <I>N</I>-(<I>p</I>-toluoyl)-<I>p</I>-toluenesulfonamide (<B>2</B>) from the same aluminum ion-doped silica gel. Their catalytic effects upon 2,4-dinitrophenolysis of benzoic anhydride, <I>p</I>-, <I>m</I>-, and <I>o</I>-toluic anhydrides were compared in order to find any difference in substrate specificities. The catalyst prepared by imprinting with <B>1</B> showed the largest specificity(<I>k</I><SUB>cat</SUB>⁄<I>K</I><SUB>m</SUB>) toward benzoic anhydride, whereas the catalyst prepared with <B>2</B> showed the largest specificity toward <I>p</I>-toluic anhydride. This finding evidently demonstrated that the substrate specificities of footprint catalytic sites are alterable, as required through selecting appropriate transition state analogs as template molecules for footprint marking.
- 公益社団法人 日本化学会の論文
著者
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TANAKA Eiko
Department of Clinical Physiology ,Chest Disease Research Institute, Kyoto University
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Takeuchi Yuko
Department Of Biology College Of General Education Osaka University
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Morihara Kensaku
Department Of Chemistry Faculty Of Science Nara Women's University
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Shimada Toyoshi
Department Of Chemical Engineering Nara National College Of Technology
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MORIHARA Kensaku
Department of Chemistry, Faculty of Science, Nara Women's University
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Miyazaki Kazue
Department of Chemistry, Faculty of Science, Nara Women's University
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Yamamoto Nami
Department of Chemistry, Faculty of Science, Nara Women's University
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Sagawa Yoshimi
Department of Chemistry, Faculty of Science, Nara Women's University
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Kawamoto Eriko
Department of Chemistry, Faculty of Science, Nara Women's University
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Yamamoto Nami
Department of Chemistry, Faculty of Science, Nara Women's University
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Kawamoto Eriko
Department of Chemistry, Faculty of Science, Nara Women's University
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Sagawa Yoshimi
Department of Chemistry, Faculty of Science, Nara Women's University
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Tanaka Eiko
Department of Chemistry, Faculty of Science, Nara Women's University
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- Footprint catalysis. III. Inducible alteration of substrate specificities of silica(alumina) gel catalysts for 2,4-dinitrophenolysis of toluic anhydrides by footprint imprinting.