Uranyl ion as a highly effective catalyst for internucleotide bond formation.
スポンサーリンク
概要
- 論文の詳細を見る
Uranyl ion catalyzes the polymerization of adenosine-5′-phosphorimidazolide very efficiently in aqueous solution. Up to 95% of the input adenosine-5′-phosphorimidazolide is converted to oligoadenylates from dimer to hexadecamer when 1 mM of UO<SUB>2</SUB><SUP>2+</SUP> is used as a catalyst. The oligomeric products are predominantly 2′–5′ linked. The chain length and the regioselectivity of the resulting oligoadenylates varies greatly with the concentration of the UO<SUB>2</SUB><SUP>2+</SUP> ion catalyst and the pH of the reaction medium. A high total yield of oligouridylates up to dodecamer is also obtained by UO<SUB>2</SUB><SUP>2+</SUP> ion catalyst with high 2′–5′ regioselectivity. The oligonucleotide formation is mediated by UO<SUB>2</SUB><SUP>2+</SUP>-nucleotide complex.
- 公益社団法人 日本化学会の論文
著者
-
Sawai Hiroaki
Department Of Applied Chemistry Faculty Of Engineering Gunma University
-
Hojo Takashi
Department of Chemistry, Faculty of Technology, Gunma University
-
Kuroda Kensei
Department of Chemistry, Faculty of Technology, Gunma University
関連論文
- Arginine-modified DNA Aptamers That Show Enantioselective Recognition of the Dicarboxylic Acid Moiety of Glutamic Acid
- Lymph Node Metastasis from Breast Cancer Diagnosed by F-18 FDG Whole-body PET (Case report)
- Long-term prognostic study of carcinoembryonic antigen (CEA) and carbohydrate antigen 15-3 (CA 15-3) in breast cancer
- Properties of Solder Joints Using Sn-Ag-Bi-In Solder
- Synthesis of a New Ruthenium Complex of a Macrocyclic Ligand Containing 1, 10-Phenanthroline, and Its Photo-Mediated Covalent Binding to DNA
- Synthesis and DNA Cleaving Activity of Copper-complex of Macrocyclic Compound Containing 1, 10-Phenanthroline
- Nevel C5-Substituted 2'-Deoxyuridine Derivatives Bearing Amino-Linker Arms : Synthesis, Incorporation into Oligodeoxyribonucleotides, and Their Hybridization Properties
- Whole-breast volume perfusion images using 256-row multislice computed tomography : visualization of lesions with ductal spread
- Temperature Dependent Duplex Formation of 3'-Phosphate Bearing α-2'-Deoxyoctathymidylate Phosphorothioate and Polyriboadenylic Acid Complex
- Effect of the Carbamoyl Group Attached to an Axial Ligand Portion of a Novel Bleomycin Model on a Dioxygen Activating Reaction
- Distal Effect of Amide and Amino Groups on the Oxygen Activation Ability and Rate of the Redox Reaction of Simplified Analogs of Bleomycin
- Duplex Stabilizing Effect and Nuclease Resistant Property of Novel Oligonucleotides Containing C-2 Branched Polyamine-Bearing Deoxyinosine Derivative
- Sensitization of Europium (III) Luminescence by DTPA Derivatives
- Selective Binding and Cleavage of DNA by Stereoisomers of N, N'-Bis(phenanthrolin-2-yl)-1, 2-cyclohexanediamine Conjugates, and Their Copper Complexes
- Facile Synthesis of 5-Substituted Arabinofuranosyluracil Derivatives
- Lanthanide Ion as a Catalyst for Internucleotide Bond Formation
- Reaction of Olefin-Palladium(II) Chloride Complexes with n-Butylamine
- Uranyl ion as a highly effective catalyst for internucleotide bond formation.
- Effect of azoles as a nucleotide activating group on uranyl (VI)-ion catalyzed synthesis of oligoadenylate in aqueous solution.