Effect of azoles as a nucleotide activating group on uranyl (VI)-ion catalyzed synthesis of oligoadenylate in aqueous solution.
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概要
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Various adenosine-5′-phosphorazolides were prepared from adenosine-5′-phosphate and azoles such as 2-methylimidazole, 4-methylimidazole, 1,2,4-triazole, 3-nitro-1,2,4-triazole, benzimidazole and 2-methylbenzimidazole. The adenosine-5′-phosphorazolides obtained were then polymerized in neutral aqueous solution using uranyl(VI) ion as a catalyst. Oligoadenylates up to the hexadecamer with 2′-5′-internucleotide linkage were formed in high yields under the optimum condition. The azoles worked as adenylate activating group, and had a large effect on the rate of polymerization, the yield and the chain length of the resulting oligonucleotides. Imidazolides showed the moderate reactivity and gave oligoadenylates of the longest chain length. From the phosphortriazolides, only short-chained oligoadenylates were obtained, as they are susceptible to the hydrolysis. Polymerization and hydrolysis reaction of the benzimidazolides were retarded.
- 公益社団法人 日本化学会の論文
著者
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Sawai Hiroaki
Department Of Applied Chemistry Faculty Of Engineering Gunma University
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Kuroda Kensei
Department of Chemistry, Faculty of Technology, Gunma University
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Shibusawa Takashi
Department of Chemistry, Faculty of Technology, Gunma University
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- Effect of azoles as a nucleotide activating group on uranyl (VI)-ion catalyzed synthesis of oligoadenylate in aqueous solution.