A New Synthesis of Aziridines from β-Amino Alcohols with Triphenylphosphine Dibromide

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概要

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• The reaction of β-amino alcohols with triphenylphosphine dibromide was found to give the corresponding aziridines in good yields. The reaction opened a new route to the synthesis of aziridine compounds which seems to be more convenient than the Gabriel and Wenker methods. In the ring closure of ephedrine, a Walden inversion was observed. A possible mechanism is suggested.

• 公益社団法人 日本化学会の論文

著者

• Sudo Rokuro

  Laboratory of Organic Chemistry Tokyo Institute of Technology

• Ichimura Kunihiro

  Laboratory of Organic Chemistry, Tokyo Institute of Technology

• Ichimura Kunihiro

  Laboratorium für Organische Chemie, Tokio Institut für Technologies, Tokio

• Okada Itaru

  Laboratory of Organic Chemistry, Tokyo Institute of Technology

関連論文

• Reactions of Aziridines with Acetyl Chloride and Related Compounds
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• A New Synthesis of Aziridines from β-Amino Alcohols with Triphenylphosphine Dibromide
• The Preparation of α-Amino-α-benzylmercaptopropionic Acid Derivatives
• Notiz zur Umsetzung des Ketenimins

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