Determination of the Optical Purity of Amino Acids by Complex Formation. Determination of Optimum Condition for Rotational Measurement

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概要

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• A new method has been established for the determination of the optical purity of a small amount of amino acids (alanine, valine, leucine, and glutamic acid). The method utilizes the fact that when an optically active amino acid is dissolved in an alkaline solution of K[Co(acac<SUB>2</SUB>en)(gly)<SUB>2</SUB>], the solution shows much larger optical rotation than the free amino acid in the visible region. 1/50 to 1/100th the amount of an amino acid (about 0.1– 0.05 grams) suffices for the determination of optical purity as compared with that needed in the usual method. The optimum conditions for measurement are: wavelength, 500 nm; pH, 10.00; time required to establish the substitution equilibrium, 6–8 hours; concentration of the complex, (4–5)×10<SUP>−3</SUP> mol l<SUP>−1</SUP>; concentration of amino acid, (2–1)×10<SUP>−2</SUP> mol l<SUP>−1</SUP>

• 公益社団法人 日本化学会の論文

著者

• Fujii Yuki

  Department Of Chemistry Faculty Of Science Ibaraki University

• Fujii Yuki

  Department of Chemistry, Faculty of Science, Hiroshima University

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