Synthesis of Sequential Polypeptides of L-Leucine and Glycine
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概要
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The following sequential polypetides of L-leucine and glycine were synthesized: (Leu<SUB>3</SUB>Gly)<I><SUB>n</SUB></I>, (Leu<SUB>2</SUB>Gly)<I><SUB>n</SUB></I>, (LeuGly)<I><SUB>n</SUB></I>, and (LeuGly<SUB>2</SUB>)<I><SUB>n</SUB></I>. Polymerization was achieved by self-condensation of the corresponding peptide <I>p</I>-nitrophenyl esters. Hydrolysis of the polypeptides were carried out in 90% aqueous trifluoroacetic acid and the time course of liberation of leucine from each polymer was presented. Apparent first-order rate constants (×10<SUP>2</SUP>), 1.93, 2.86, 2.91, and 4.4 hr<SUP>−1</SUP> were obtained for liberation of leucine from (Leu<SUB>3</SUB>Gly)<I><SUB>n</SUB></I>, (Leu<SUB>2</SUB>Gly)<I><SUB>n</SUB></I>, (LeuGly)<I><SUB>n</SUB></I>, and (LeuGly<SUB>2</SUB>)<I><SUB>n</SUB></I>, respectively.
- 公益社団法人 日本化学会の論文
著者
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Takahashi Sho
Institute For Chemical Research Kyoto University
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Iio Takayoshi
Department Of Physics Faculty Of Science Nagoya University
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