Synthesis of [2-serine, 8-valine]-human calcitonin.

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概要

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• The [2-serine, 8-valine]-analog of human calcitonin (<B>1</B>) was synthesized by the liquid phase method. Analog <B>1</B> was built up from five fragments with minimized protection for the side functional groups. These fragments were linked step wise to the C-terminal fragments by the azide method. A gel filtration was effectively applied for the purification of the resulting pep tide in each fragment condensation. Analog <B>1</B> had about the same hypocalcemic activity as that of human calcitonin. The result showed that the high activity of eel or salmon calcitonin 1 or 2 is not ascribable only to the amino acid sequence of their <I>N</I>-terminal decapeptide.

• 公益社団法人 日本化学会の論文

著者

• Nozaki Sukekatsu

  Department of Chemistry, College of Science, Rikkyo University

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• Synthesis of [2-serine, 8-valine]-human calcitonin.
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