Alkylation and acylation of active methylene compounds using 1,8-diazabicyclo[5.4.0]undec-7-ene as a base.
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概要
- 論文の詳細を見る
Active methylene compounds are selectively monoalkylated with alkyl halides in benzene using 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as a base. Selectivity of monoalkylation decreases when the reaction is carried out in a polar solvent. Ethyl acetoacetate is O-acylated with acyl halides in the presence of DBU in acetonitrile to give the (<I>E</I>)-enol esters stereoselectively.
- 公益社団法人 日本化学会の論文
著者
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SAITO Tadashi
Department of Oral Surgery, Gunma University School of Medicine
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Ono Noboru
Department Of Chemistry Faculty Of Science Ehime University
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Tanikaga Rikuhei
Department Of Bioscience And Biotechnology Faculty Of Science And Engineering Ritsumeikan University
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Kaji Aritsune
Department of Chemistry, Faculty of Science, Kyoto University
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Tamura Rui
Department of Chemistry, Faculty of Science, Kyoto University
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Yoshimura Tetsuji
Department of Chemistry, Faculty of Science, Kyoto University
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