THE IMPORTANCE OF CALCIUM IN THE RELEASE OF CATECHOLAMINE FROM THE ADRENAL MEDULLA
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概要
- 論文の詳細を見る
The mechanism of release of catecholamine was studied using bovine adrenal medullary slices or granules.<BR>1. Acetylcholine or excess potassium caused an increase in the rate of catecholamine release from the slices. Omission of calcium from the incubation medium also stimulated the release of catecholamine.<BR>2. The stimulatory effect of acetylcholine or excess potassium was lost when calcium was omitted from the medium, and markedly inhibited by the addition of cocaine.<BR>3. Addition of reserpine or tyramine stimulated the release of catecholamine from the slices. The effect of reserpine was diminished in calcium free medium, but that of tyramine was not affected in calcium free medium. Cocaine had a weak inhibitory effect on the release of catecholamine caused by reserpine but no effect on the response to tyramine.<BR>4. Calcium ion itself stimulated the released of catecholamine from the granules, but its effect was prevented by magnesium.<BR>From the above results it is suggested that calcium ion plays a cardinal role in the process of catecholamine release from the adrenal medulla and it acts as a link between the excitation of the membrane and the secretory response.
- 公益社団法人 日本薬理学会の論文
著者
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岡 源郎
Department of Pharmacology, Faculty of Medicine, Osaka University
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大内 武
Department of Pharmacology, Faculty of Medicine, Osaka University
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吉田 博
Department of Neuropharmacology and Neurochemistry, Institute of Higher Nervous Activity, Faculty of
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今泉 礼治
Department o f Pharmacology, Faculty of Medicine, Osaka University
関連論文
- STIMULATORY EFFECT OF ADENOSINE TRIPHOSPHATE AND MAGNESIUM ON THE RELEASE OF CATECHOLAMINES FROM ADRENAL MEDULLARY GRANULES
- SUBCELLULAR ASCORBIC ACID IN SCORBUTIC GUINEA PIG BRAIN
- MONOAMINE OXIDASE ACTIVITY AND MITOCHONDRIAL STRUCTURE OF THE BRAIN
- BREAKDOWN OF HIGH ENERGY PHOSPHATE COMPOUNDS IN BRAIN SLICES IN RELATION WITH AN INCREASE IN PERMEABILITY TO CATIONS
- THE UPTAKE OF CATECHOLAMINES BY SUBCELLULAR GRANULES IN THE BRAIN STEM
- EFFECT OF DOPA ON THE NOREPINEPHRINE AND DOPAMINE CONTENTS AND ON THE GRANULATED VESICLES OF THE HYPOTHALAMUS OF RESERPINIZED RABBITS
- INHIBITIONS BY OUABAIN AND PROTOVERATRINE ON ACTIVE TRANSPORT OF L-DOPA INTO BRAIN SLICES
- EFFECT OF RESERPINE ON SPONTANEOUS RELEASE OF NOREPINEPHRINE ACCUMULATED IN MITOCHONDRIAL FRACTION OF BRAIN STEM OF GUINEA PIG
- NORADRENALINE IN THE CAUDATE NUCLEUS OF THE RABBIT
- EFFECTS OF RESERPINE AND OXYPERTINE ON ACCUMULATION OF NOREPINEPHRINE IN MITOCHONDRIAL FRACTION OF BRAIN STEM OF GUINEA PIG
- STUDIES ON ACTIVE TRASPORT OF L-DOPA (DIHYDROXYPHENYLALANINE) INTO BRAIN SLICES
- INHIBITION OF BRAIN DOPAMINE β-OXIDASE IN VIVO BY DISULFIRAM
- MOVEMENT OF RADIOACTIVE CALCIUM IN BRAIN SLICES AND INFLUENCES ON IT OF PROTOVERATRINE, OUABAIN, POTASSIUM CHLORIDE AND COCAINE
- THE IMPORTANCE OF CALCIUM IN THE RELEASE OF CATECHOLAMINE FROM THE ADRENAL MEDULLA
- INCREASE IN DESTRUCTION OF CREATINE PHOSPHATE IN GUINEA PIG BRAIN SLICES BY OUABAIN AND THE PREVENTION OF THIS CHANGE BY COCAINE