STUDIES ON ACTIVE TRASPORT OF L-DOPA (DIHYDROXYPHENYLALANINE) INTO BRAIN SLICES
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概要
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It is known that catecholamine has an important role to regulate function of the brain. The sedation caused by reserpine, accompanying a decrease in the content of catecholamine in brain, is restored by administration of dopa (1-4). These results suggest that dopa is a precursor of catecholamine in brain and taken up into brain tissue from circulation system, through blood brain barrier and cell membrane, though catecholamine is considered to be difficult to permeate the blood brain barrier. Therefore, transport process of dopa into brain cell through cell membrane may have physiological meanings.<BR> On the other hand, transport process at cell membrane is one of the most attractive biological problems. Active accumulation of amino acid in brain slices against concentration gradient has been known since a report of Stern (5), but the mechanism is remained in unclear. We examined transport of dopa into brain slices to get a clue to clarify mechanism of active transport of amino acid.
- 公益社団法人 日本薬理学会の論文
著者
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吉田 博
Department of Neuropharmacology and Neurochemistry, Institute of Higher Nervous Activity, Faculty of
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今泉 礼治
Department o f Pharmacology, Faculty of Medicine, Osaka University
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蟹池 健一
Department of Pharmacology, Faculty of Medicine, Osaka Uniosrsity
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今泉 礼治
Department of Pharmacology, Faculty of Medicine, Osaka Uniosrsity
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難波 仁
Department of Pharmacology, Faculty of Medicine, Osaka Uniosrsity
関連論文
- STIMULATORY EFFECT OF ADENOSINE TRIPHOSPHATE AND MAGNESIUM ON THE RELEASE OF CATECHOLAMINES FROM ADRENAL MEDULLARY GRANULES
- SUBCELLULAR ASCORBIC ACID IN SCORBUTIC GUINEA PIG BRAIN
- MONOAMINE OXIDASE ACTIVITY AND MITOCHONDRIAL STRUCTURE OF THE BRAIN
- BREAKDOWN OF HIGH ENERGY PHOSPHATE COMPOUNDS IN BRAIN SLICES IN RELATION WITH AN INCREASE IN PERMEABILITY TO CATIONS
- THE UPTAKE OF CATECHOLAMINES BY SUBCELLULAR GRANULES IN THE BRAIN STEM
- EFFECT OF DOPA ON THE NOREPINEPHRINE AND DOPAMINE CONTENTS AND ON THE GRANULATED VESICLES OF THE HYPOTHALAMUS OF RESERPINIZED RABBITS
- INHIBITIONS BY OUABAIN AND PROTOVERATRINE ON ACTIVE TRANSPORT OF L-DOPA INTO BRAIN SLICES
- EFFECT OF RESERPINE ON SPONTANEOUS RELEASE OF NOREPINEPHRINE ACCUMULATED IN MITOCHONDRIAL FRACTION OF BRAIN STEM OF GUINEA PIG
- NORADRENALINE IN THE CAUDATE NUCLEUS OF THE RABBIT
- EFFECTS OF RESERPINE AND OXYPERTINE ON ACCUMULATION OF NOREPINEPHRINE IN MITOCHONDRIAL FRACTION OF BRAIN STEM OF GUINEA PIG
- STUDIES ON ACTIVE TRASPORT OF L-DOPA (DIHYDROXYPHENYLALANINE) INTO BRAIN SLICES
- RELATIONSHIP OF HYPERKALEMIC RESPONSE TO HEPATIC PHOSPHORYLASE ACTIVATION INDUCED BY ADRENALINE
- INHIBITION OF BRAIN DOPAMINE β-OXIDASE IN VIVO BY DISULFIRAM
- MOVEMENT OF RADIOACTIVE CALCIUM IN BRAIN SLICES AND INFLUENCES ON IT OF PROTOVERATRINE, OUABAIN, POTASSIUM CHLORIDE AND COCAINE
- THE IMPORTANCE OF CALCIUM IN THE RELEASE OF CATECHOLAMINE FROM THE ADRENAL MEDULLA
- INCREASE IN DESTRUCTION OF CREATINE PHOSPHATE IN GUINEA PIG BRAIN SLICES BY OUABAIN AND THE PREVENTION OF THIS CHANGE BY COCAINE