THE PHARMACOLOGICAL ACTION OF AMINES ON GUINEA PIG SMALL INTESTINE
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概要
- 論文の詳細を見る
To seek for the toxic substances in rotten fish which induce vomiting and diarrhea, experiments were carried out with putrescine, agmatine, neurine and tyramine. The following results were obtained : <BR>1. Agmatine and tyramine have no effect on the serosa of the excised intestine of a guinea pig, but 1 mg/ml × 1/50 of neurine induces a contraction of the intestine, and 1 μg/ml × 1/50 of putrescine likewise induces a contraction.<BR>2. Putrescine, agmatine and tyramine have no effect on the mucosa of the intestine <I>in vivo</I>, but 10 mg/ml of neurine induces a contraction.<BR>3. When each amine is combined with histamine, agmatine is synergistic to the latter by sensibilization; neurine additionally synergistic, while tyramine antagonistic to it. Putrescine does not act on the intestine.
- 公益社団法人 日本薬理学会の論文
著者
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Ito Kenji
Department Of Anesthesiology Tokai University School Of Medicine
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SONO ISAO
Department of Pharmacology, Mie Prefectural University School of Medicine
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NISHIYAMA MASAO
Department of Pharmacology, Mie Prefectural University School of Medicine
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MIWA TAKIO
Department of Pharmacology, Mie Prefectural University School of Medicine
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KOKUBU JOFU
Department of Pharmacology, Mie Prefectural University School of Medicine
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FUJII KIICHIRO
Department of Pharmacology, Mie Prefectural University School of Medicine
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SHIIKI YASUTO
Department of Pharmacology, Mie Prefectural University School of Medicine
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IWAO ISAMU
Department of Pharmacology, Mie Prefectural University School of Medicine
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TERADA YASUKAZU
Department of Pharmacology, Mie Prefectural University School of Medicine
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