The effect of racemomycin-D, a nephrotoxic antibiotic, on cellular metabolism of rat kidney cortex in vitro.
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概要
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In vitro effects of racemomycin-D on cellular metabolism were examined in rat kidney. Racemomycin-D decreased the concentration gradient of Na<SUP>+</SUP> and K<SUP>+</SUP> across the cell membranes, but failed to influence water content and ATP concentration of kidney cortical slices. The antibiotic inhibited microsomal (Na<SUP>+</SUP>+K<SUP>+</SUP>) - ATPase. Preincubation of the microsomes with racemomycin-D enhanced the inhibition about 1.8-fold. Succinoxidase activity of mitochondria remained unaltered in the presence of racemomycin-D, but the antibiotic potently decreased ATP-dependent Ca<SUP>2+</SUP> and Mg<SUP>2+</SUP> uptakes by mitochondria. These results suggest that racemomycin-D probably disorders intracellular homeostasis of Na<SUP>+</SUP>, K<SUP>+</SUP> and Ca<SUP>2+</SUP>.
- 公益社団法人 日本薬理学会の論文
著者
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Inamori Yoshihiko
Department Of Microbiology Osaka College Of Pharmacy
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Kato Yoshiaki
Department Of Biotechnology Faculty Of Engineering Kansai University
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INAMORI Yoshihiko
Departments of Microbiology
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KUBO Mayuri
Departments of Microbiology
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NAKANISHI Jun-ichi
Pharmacology, Osaka College of Pharmacy
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NAKASHIMA Mayumi
Pharmacology, Osaka College of Pharmacy
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GEMBA Munekazu
Pharmacology, Osaka College of Pharmacy
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KATO Yoshiaki
Departments of Microbiology
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- The effect of racemomycin-D, a nephrotoxic antibiotic, on cellular metabolism of rat kidney cortex in vitro.