GC-MSによるrT<SUB>3</SUB>と33′T<SUB>2</SUB>の同時分析:第2報 : MFによるrT<SUB>3</SUB>と33′T<SUB>2</SUB>の同定
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In view of the previous report of the possibility of 33′-T2 and r-T3 measurements, the identification of these iodinated compounds was performed by mass fragmentography. The peaks at m/e 218,624 (33′-T2) and m/e 218,750 (r-T3) were applied to establish the precise qualitative evaluation of unknown peaks. The base peak at m/e 218 (thyroid analogues) was applied to avail itself of simultaneous multiple ion analyses by GC-MS. The following results were obtained.<BR>1) Mass fragmentography makes possible the simultaneous measurements of 33′-T2, r-T3 and other thyroid analogues with 1 ml of serum and urine samples obtained from rats or human beings.<BR>2) This method is very convenient for extracting the compounds from biological fluids, and the procedure can be carried out easily in a short time. The specificity of this method surpasses and cannot be compared to any other existing quantitative methods.
- 一般社団法人 日本内分泌学会の論文
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