アンジオテンシンIIアナローグ ([Sar1, Ile8] Angiotensin II) に関する研究:1) 血圧, 血漿レニン活性および血漿アルドステロンにおよぼす影響について

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To investigate the effects of an analogue of angiotensin II (ATII), [Sar1, Ile8] ATII, on blood pressure, plasma renin activity (PRA), and plasma aldosterone (PA), the analogue was intravenously infused at a constant rate of 600 ng/kg/min for 30 minutes into 6 normal subjects and 37 untreated patients suffering from various forms of hypertension. Pressor responses with a peak at 5 to 10 minutes occurred in normal subjects and 18 essential hypertensive patients with low or normal PRA. Thirty minutes after infusion, a significant decrease in PRA with an increase in PA was observed with or without a significant increase in blood pressure in essential hypertensive patients with low or normal PRA as was also ob-served in normal subjects. On the other hand, in 8 essential hypertensive patients with high PRA, a patient with renal artery stenosis and high PRA and 3 patients with renovascular hypertension on a low sodium diet, the analogue induced a gradual decrease in blood pressure with an increase in PRA and a decrease in PA. In 2 hypertensive patients with high PRA, the analogue caused severe hypotension with bradycardia. In 4 patients with primary aldosteronism, a significant increase in blood pressure was observed without significant changes in either PRA or PA during the [Sar1, Ile8] ATII infusion. These results suggest that [Sar1, Ile8] ATII acts as a weak agonist under the normal or low secretion of renin, but as an antagonist under an excess of renin release in man, except for primary aldosteronism in which a discrepant agonistic action between vasculature and kidney or adrenal cortex was observed. From the activity of agonistic or antagonistic action of the ATII analogue, the usefulness of [Sar1, Ile8] ATII in making an etiological diagnosis of hypertension was discussed.
日本内分泌学会の論文

アンジオテンシンIIアナローグ ([Sar<SUP>1</SUP>, Ile<SUP>8</SUP>] Angiotensin II) に関する研究:1) 血圧, 血漿レニン活性および血漿アルドステロンにおよぼす影響について

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