Catecholestrogen 2-monomethyl etherの血清コレステロール低下作用

概要

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The hypocholesterolemic effect of 2-methoxyestrone (2-MeOE1), 2-methoxyestriol (2-MeOE3) and estradiol-17β (E2-17β) was investigated in two experimental systems of normocholesterolemic and dietary hypercholesterolemic rats that had undergone oophorectomy. Each compound was subcutaneously administered for 6 consecutive days at a dose of 10μg per day in the former systems and at 300μg per day in the latter system, respectively. The hypocholesterolemic effect was in the following relation : 2-MeOE3 ≅ : E2 -17β>2-MeOE1. In the latter system, the serum total cholesterol level of individual rats in both 2-MeOE3- and E2-17β-administered groups returned to normal. No uterotrophic activity was exhibited by either 2-MeOE1 or 2-MeOE3, while E2 -17β exhibited an anomalous activity. The effect of 2-MeOE1 and 2-MeOE3 on body weight was not exhibited, while E2 -17β reduced it slightly. The results suggest that catecholestrogen 2-monomethyl ether plays an important role in lipid metabolism through estrogen receptor independent mechanisms and has a pharmacologically important effect on hyperlipidemia and atherosclerosis.
一般社団法人日本内分泌学会の論文