前眼房内へ移植した胎生雌ラット前脳基底核コリン作動性ニューロンに対するエストロゲンの影響の組織化学的検討

概要

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In order to clarify the effects of estrogen on cholinergic basal forebrain neurons, a cholinergic neuron in the diagonal band nucleus of the female fetal rat was implanted into the anterior eye chamber of the female adult rat. Some host rats were treated with 2mg estradiol valerate (E<SUB>2</SUB>v) injected every 3 days after ovariectomy while others were not. 2 and 4 weeks after transplantation, the growth of cholinergic neurons in the graft was studied using acethylcholinesterase (AChE) histochemistry. At 2 weeks after transplantation, AChE positive neurons and fibers were densely distributed in the grafts of av treated rats. Also in grafts without E<SUB>2</SUB>v treatment, AChE positive neurons and fibers were found in all the grafts although their density was low. At 4 weeks, AChE staining was dense staining observed in both groups. These results indicate the neurotrophic effect of estrogen on the cholinergic basal forebrain neurons.
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