レーザー光散乱による赤血球集合・沈降過程の解析

概要

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The mechanism of erythrocyte aggregation and sedimentation is studied by laser light scattering method. He-Ne laser light of 632.8nm is passed through a well mixed sample of blood, allowed to settle under the gravitational field in a chamber. The forward scattered light intensity at the middle height of erythrocyte suspension column is recorded continuously. Initially there is a small and smooth variation in output signal is observed. After few minutes, fluctuations in the signal are observed, they are small and well defined in the beginning and later become large and random. The saturation of the signal with maximum intensity indicates the completion of the sedimentation process at the observation point. From this light signal pattern various parameters are obtained to explain the mechanism of erythrocyte aggregation and sedimentation. Alterations in these parameters due to influence of dextrans (Dx 70 and Dx 500) are studied. The results are compared with aggregate microphotographs.
特定非営利活動法人日本バイオレオロジー学会の論文