前立腺癌における基底膜の変化と転移:ラミニンによる免疫組織学的検討

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Immunoreactivity in 16 cases of prostatic adenocarcinoma and 5 normal/hyperplastic prostates were investigated in methacarn-fixed, paraffin-embedded sections using anti-laminin monoclonal antibody (MAB1920, chemicon).<BR>In normal/hyperplastic prostates, laminin Immunoreactivity showed distinct continuous basement membrane around the prostatic ducts/acini and the stroma (capillary, small blood vessel, smooth muscle and nerve).<BR>In prostatic carcinomas, the structural pattern of basement membrane formation dependended on the histological differentiation. The well differentiated adenocarcinoma showed continuous basement membrane comparable to normal glands. The poorly differentiated adenocarcinomas usually had widespread absence of laminin immunoreactivity. The prostatic acinar laminin reactivity was inversely proportioned to the degree of dedifferentiation.<BR>In our investigation no correlation between laminin reactivity on prostatic carcinomas and bone metastasis was found.
Kinki Brain Tumor Pathology Conferenceの論文