リピッド膜の相転移における臨界揺動に伴う圧縮率と比容 I.

概要

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Thermodynamic equations for phase transition of dimyristoylphosphatidylcholine (DMPC) are calculated numerically by using the Gibbs free energy per one mole of hydrocarbon chains that is given by Sugár as G/RT=F/RT+pV/RT+πA/2RT, where R is the gas constant, T is the absolute temperature, p the pressure, π the osmotic lateral pressure. The free energy F, the molar specific volume V and the molar specific area A are written as functions of the disorder parameter S. The compressibility B=-(1/V) (dV/dS) (dS/dp) is obtained as well as V against the temperature, the pressure and the lateral pressure. In DMPC we have the critical point where πc=-0.01712N/m and Tc=273.15+22.06 K at the atmospheric pressure p=0. At the critical point B increases anomalously and V changes continuously from the disordered state as varying π. Contrarily as more increasing p, V changes more discontinuously and B behaves less anomalously at the first transition point. The results are compared with experiments for pressure dependence of V in DMPC liposome suspension.
特定非営利活動法人日本バイオレオロジー学会の論文