ナットウ菌由来タンパク質のヒト血液凝固線溶系におよぼす影響について

概要

論文の詳細を見る
NKCP is the fragment of a part of Bacillopeptidase F from Natto bacteria (Bacillus natto), supplied as the tablet without distinct odor, bacterial cells nor vitamin K. The daily oral administration of NKCP, 28 volunteers for two weeks and 23 volunteers for several months, were examined to evaluate anti-thrombotic and fibrinolytic effect of the NKCP for humans.<BR>The fibrinolytic effect was observed with shortering eugloburin lysis time in both trials without any significant changes in other coagulation and fibrinolytic parameters. Furthermore, we observed the statistically significant change of shoulder stiffness. These results suggest that oral administration of NKCP has the fibrinolytic effect and the improvement of local blood flow. With further in vivo investigation, NKCP May be used as the preventing substrate from thrombotic disease.