痰のシアル酸, フコースとレオロジカルな性状について

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The comparative studies were carried out on the rheological properties (yield value, spinnability and fluidity) and the concentrations of sialic acid and fucose of 226 samples of sputum collected from patients with chronic respiratory diseases under clinically stable states.<BR>Spinnability was measured with an apparatus devised by Nagaoka and Yamanaka and yield value was measured by Barnett and Dulfano's double capillary method.<BR>Fluidity of the sputum was determined as follows. One ml of sputum was filled into one end of a glass tube. This glass tube was then slanted at an angle of 45° to allow the sputum to flow down. Time in seconds required for the specimen to move over a distance of 10cm was taken as an index of fluidity.<BR>Sialic acid concentration was correlated with both the spinnability (r=0.222, p<0.01) and the fluidity (r=0.428, p<0.001 ), while fucose concentration was correlated with the fluidity only (r=0.268, p<0.02). Thus we assume that the rheological properties of sputum are more significantly influenced by the acid fraction rather than the neutral fraction of glycoproteins. (J. Jpn. Soc. Biorheol., 1 (3), 22-28, 1987).
特定非営利活動法人日本バイオレオロジー学会の論文