Corticosterone分泌量に関する研究とくに健常者並びに各種高血圧患者における分泌量について
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The corticosterone secretion rate was studied by an isotope dilution method in 16 resting, 9 lightly working and 7 heavily working normal subjects and 6 patients with essential hypertension, 5 with renovascular hypertension and in 5 with primary aldosteronism.<BR>No significant difference was found in the rate of corticosterone secretion among the three groups of resting normal subjects, light workers and heavy workers.<BR>The corticosterone secretion rate in 25 normal subjects (16 resting subjects and 9 light workers) varied between 1.5 mg and 4.3 mg per day with a mean of 2.6 mg per day.<BR>No significant correlation was observed between the corticosterone secretion rate and body weight or body surface area.<BR>ACTH stimulation induced a remarkable increase (more than tenfold) in the rate of corticosterone secretion in 2 normal subjects. A low value, 0.3 mg per day, was obtained in a patient with panhypopituitarism due to craniopharyngioma.<BR>The corticosterone secretion rate in 6 patients with benign essential hypertension and 5 with renovascular hypertension was observed to remain within the normal range.<BR>In two out of five patients with primary aldosteronism due to adrenal adenoma, the secretion rate of corticosterone was significantly elevated, whereas in the other 3 it was within the normal range. Compared with the latter, those two cases with the higher corticosterone secretion revealed to have a lower serum potassium concentration and a more elevated potassium clearance measured after sodium thiosulfate loading. From this result it is suggested that corticosterone plays a role in the potassium metabolism in man.
- 日本内分泌学会の論文
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