I<SUP>131</SUP>-TSHに関する研究:第1篇 分子状ヨードによるTSHの不活性化について

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概要

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• Using I<SUP>131</SUP>-TSH which was prepared by iodination, the relationship between TSH and thyroid gland, especially the mechanism of active and inactive TSH, the mode of action of Lugol's solution on Grave's disease and that of Mercazol (1-methyl-2-mercaptoimidazole) on thyroid, were investigated.<BR>The results were as follows : <BR>1) I<SUP>131</SUP>-TSH was made by the reaction between elemental iodine (I<SUB>2</SUB><SUP>127</SUP>) and TSH (Pretiron), using radioiodine I<SUP>131</SUP> as a tracer.<BR>2) The saturatedly iodinated TSH was lost its biological activity with iodination, but many differently active TSH was possible to make by different grade of iodination.<BR>3) TSH (Pretiron) 500 JS/18mg contained 5.15% of tyrosine, and 0.53% of tryptophan, while none of cysteine and iodine.<BR>4) In TSH 1 JS, the amount of tyrosine was 1.83γ and TSH 1 JS was saturated by 2.5γ of iodine and then its activity was lost completely with iodination.<BR>When tyrosine residue of TSH was iodinated, tyrosine residue was changed to DIT.<BR>I<SUB>2</SUB> molecular weight/Tyrosine molecular weight =254.84/181.09=1.4/1<BR>From this result it was ascertained that the experimental result was coincided with the theoretical value, that tyrosine residue only participated in the iodination of TSH and that absolutly necessary residue for the activity of TSH was tyrosine.<BR>5) If the molecular weight of TSH was 10,000, 1 Mol of TSH would contain 2 or 3 tyrosine residue and this TSH would be saturated with 4 or 6 iodine.<BR>6) In Graves disease which cause was seemed to be the hypersecretion of TSH from pituitary gland, it is presumed that the action of Lugol's solution is inactivation of TSH by the formation of iodinated TSH which was made in proportion to the elevated concentration of TSH.<BR>7) The mechanism of action of Mercazol was mainly the inhibition of TSH iodination by the reduction of elemental iodine.

• 日本内分泌学会の論文

著者

• 越智 幸男

  京都府立医大第二内科

• 越智 幸男

  京都府立医科大学第二内科

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