実験的糖尿病家兎血清脂質に及ぼすグルカゴンの影響

概要

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It is frequently encountered that the serum of the rabbits with experimental diabetes become turbid or chylous. It is known that in these rabbits the concentrations of total cholesterol, total and neutral fats are exceedingly high. A study was undertaken to investigate the effect of glucagon on the severe lipemia in rabbits with experimental diabetes, and the following results were obtained : <BR>(1) Approximately seven-fold increase in serum cholesterol was observed by a single injection of dithizone alone whereas the increase was only three-fold in animals received daily injections of 20-30γ /kg. of PVP-glucagon following dithizone injection. When the dose of glucagon was increased to 120γ /kg in the same animals, no further increase in serum total cholesterol occured and even transient decrease was observed. Turbidity of the serum in these animals paralleled to the change of serum cholesterol. <BR>(2) Intravenous administration of 400γ /kg of glucagon 10 minutes prior to the alloxan injection appeared to prevent the diabetes produced by alloxane. However, in a rabbit received 200γ/kg of glucagon intravenously 10 minutes prior to dithizone injection development of diabetes was observed. The increase of serum total cholesterol in these animals was none or less marked as compared with that of control animals, and the serum remained clear.
日本内分泌学会の論文