インシユリンの血糖降下作用に及ぼすSH化合物の影響

概要

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In 1931, du Vigneaud reported that the hypoglycemic action of insulin was abolished when it was mixed with cysteine or glutathione, which were sulfhydryl compounds, before administration. Later, Wintersteiner also observed in vitro inactivation of insulin by thioglycollic acid or thiolactic acid.<BR>It had been reported by us that BAL or sodium thiolactate prevented the production of dithizone diabetes. The effects of these compounds on hypoglycemic action of insulin were further investigated, and the following results were obtained:<BR>(1) When insulin was mixed with sulfhydryl compounds such as sodium thiolactate or sodium mercaptoacetate prior to the administration, its hypoglycemic action was partially or completely inhibited.<BR>(2) When sodium thiolactate, BAL or sodium mercaptoacetate was administered prior to the insulin injection, similar inhibiting effects of these compounds on insulin hypoglycemic action were observed.<BR>(3) No such effect of sodium thiosulfate was seen.
日本内分泌学会の論文