Multimarker Approach for the Prediction of Cardiovascular Events in Patients With Mild to Moderate Coronary Artery Lesions
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概要
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Few studies have assessed the incremental usefulness of multimarkers as predictors of cardiovascular events in patients with mild to moderate coronary artery lesions.We examined 9 plasma inflammatory cytokines (cathepsin S, CXCL16, sopluble CD40 ligand, interleukin-10, placental growth factor, GDF15, matrix metalloproteinase 9, monocyte chemoattractant protein-1, and high-sensitivity C-reactive protein) in 964 patients showing mild to moderate lesions and assessed their association with risk of cardiovascular events during 3 years of follow-up (median 17 months).In a backward Cox regression procedure, Cystatin S (hazard ratio [HR]: 1.788, 95% CI:1.233 to 2.593, P = 0.02), soluble CD40 ligand (HR: 1.255, 95% CI:1.054 to 1.494, P = 0.011), placental growth factor (HR: 1.194, 95% CI:0.976 to 1.461, P = 0.035), and GDF15 (HR: 0.725, 95% CI:0.550 to 0.956, P = 0.023) were significantly related to cardiovascular events. Compared with multimarker score (according to regression coefficients of significant biomarkers) in the lowest two quintiles, patients in the highest quintile had a higher risk of cardiovascular events after adjustment for traditional risk factors (HR: 2.77, 95% CI:1.30 to 5.87, P = 0.008). Adding the multimarker score to traditional risk factors contributed significantly to the prediction of cardiovascular events (AUC increased from 0.67 to 0.72).A multimarker approach added to the predictive information obtained from traditional risk factors in patients with mild to moderate coronary artery lesions.
著者
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HUO Yong
Department of Cardiology , Peking University First Hospital
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Chen Fang
Department Of Cardiology Beijing Anzhen Hospital Capital Medical University
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ZHOU Yujie
Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University
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Zhang Min
Department Of Agricultural Biochemistry And Biotechnology Tottori University
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Li Hong
Department Of Agricultural And Biosystems Engineering Iowa State University
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Chen Fang
Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University
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HUO Yong
Department of Cardiology, Peking University First Hospital
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Wu XiaoFan
Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University
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Chen YunDai
Department of Cardiology, Chinese PLA General Hospital
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Jin Zening
Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University
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Song Xiantao
Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University
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Lu Shuzheng
Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University
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