Diarylheptanoids from Alnus japonica Inhibit Papain-Like Protease of Severe Acute Respiratory Syndrome Coronavirus

スポンサーリンク

概要

• 論文の詳細を見る

• The papain-like protease (PLpro), which controls replication of the severe acute respiratory syndrome coronavirus (SARS-CoV), has been identified as a potential drug target for the treatment of SARS. An intensive hunt for effective anti-SARS drugs has been undertaken by screening for natural product inhibitors that target SARS-CoV PLpro. In this study, diarylheptanoids 1–9 were isolated from Alnus japonica, and the inhibitory activities of these compounds against PLpro were determined. Of the isolated diarylheptanoids, hirsutenone (2) showed the most potent PLpro inhibitory activity, with an inhibitory concentration (IC50) value of 4.1 µM. Structure–activity analysis showed that catechol and α,β-unsaturated carbonyl moiety in the molecule were the key requirement for SARS-CoV cysteine protease inhibition.

著者

• Kim Doman

  School Of Biological Sciences And Technology And Institute Of Bioindustrial Technology Jeonnam Natio

• Park Su-jin

  Infection Control Material Res. Center And Ai Control Material Res. Center Korea Res. Inst. Of Bioscience And ...

• Bae Ryu

  Infection Control Material Research Center, Korea Research Institute of Bioscience and Biotechnology

• Jeong Hyung

  Infection Control Material Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)

• Kim Jang

  Infection Control Material Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)

• Park Ji-Young

  Infection Control Material Research Center, Korea Research Institute of Bioscience and Biotechnology

• Hoon Kim

  Infection Control Material Research Center, Korea Research Institute of Bioscience and Biotechnology

• Min Kim

  Infection Control Material Research Center, Korea Research Institute of Bioscience and Biotechnology

• Hun Park

  Division of Applied Life Science (BK 21 Program, IALS), Graduate School of Gyeongsang National University

• Song Lee

  Infection Control Material Research Center, Korea Research Institute of Bioscience and Biotechnology

• Park Su-Jin

  Infection Control Material Research Center, Korea Research Institute of Bioscience and Biotechnology

• Kim Doman

  School of Biological Science and Biotechnology, Chonnam National University

関連論文

• Synthesis of Thermo- and Acid-stable Novel Oligosaccharides by Using Dextransucrase with High Concentration of Sucrose
• Molecular Cloning of cDNA for Trehalase from the European Honeybee, Apis mellifera L., and Its Heterologous Expression in Pichia pastoris
• Molecular Cloning, Functional Expression, and Tissue Distribution of a Potato Sprout Allene Oxide Synthase Involved in a 9-Lipoxygenase Pathway
• Purification and Partial Characterization of a Novel Glucanhydrolase from Lipomyces starkeyi KSM 22 and its Use for Inhibition of Insoluble Glucan Formation
• Catalytic Reaction Mechanism Based on α-Secondary Deuterium Isotope Effects in Hydrolysis of Trehalose by European Honeybee Trehalase
• Truncation of N- and C-terminal regions of Streptococcus mutans dextranase enhances catalytic activity.
• Norkurarinol Inhibits Toll-Like Receptor 3 (TLR3)-Mediated Pro-inflammatory Signaling Pathway and Rotavirus Replication
• Homoisoflavonoids from Caesalpinia sappan Displaying Viral Neuraminidases Inhibition
• Diarylheptanoids from Alnus japonica Inhibit Papain-Like Protease of Severe Acute Respiratory Syndrome Coronavirus

スポンサーリンク