The Essential Oil of Melaleuca alternifolia (Tea Tree Oil) and Its Main Component, Terpinen-4-ol Protect Mice from Experimental Oral Candidiasis
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概要
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The therapeutic efficacy of tea tree oil (TTO), Melaleuca alternifolia, and its main component, terpinen-4-ol, were evaluated in a murine oral candidiasis model. Prednisolone -pretreated mice were orally infected with a fluconazole-susceptible (TIMM 2640) or a resistant (TIMM 3163) strain of Candida albicans to induce oral candidiasis. TTO or terpinen-4-ol was administrated with a cotton swab 3 h and 24 h after candida infection. These treatments clearly showed a decrease in the symptom score of tongues and in the viable candida cell number in the oral cavity at 2 d after azole-susceptible C. albicans infection, although the degree of the efficacy was less than that of fluconazole. Even against oral candidiasis caused by azole-resistant C. albicans, TTO and terpinen-4-ol were similarly effective, while fluconazole appeared ineffective. These results suggest that TTO and terpinen-4-ol may have the potential of therapeutic ability for mucosal candidiasis which may also be applicable to C. albicans oral candidiasis induced by the azole-resistant strain.
- 公益社団法人 日本薬学会の論文
著者
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ABE SHIGERU
Institute of Medical Mycology, Teikyo University
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Abe Shigeru
Institute Of Medical Mycology Graduate School Of Medical Science Teikyo University
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Ishibashi Hiroko
Institute Of Medical Mycology Teikyo University
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Oshima Haruyuki
Department Of Bioscience School Of Science And Engineering Teikyo University
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Maruyama Naho
Institute of Medical Mycology, Teikyo University
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Takizawa Toshio
Institute of Medical Mycology, Teikyo University
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Ninomiya Kentaro
Institute of Medical Mycology, Teikyo University
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Inoue Shigeharu
Institute of Medical Mycology, Teikyo University
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Oshima Haruyuki
Department of Biosciences, Faculty of Science and Engineering, Teikyo University
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- The Essential Oil of Melaleuca alternifolia (Tea Tree Oil) and Its Main Component, Terpinen-4-ol Protect Mice from Experimental Oral Candidiasis