Inhibition of Melanogenesis by <I>Xanthium strumarium</I> L.
スポンサーリンク
概要
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<I>Xanthium strumarium</I> L. (Asteraceae) is traditionally used in Korea to treat skin diseases. In this study, we investigated the effects of a <I>X. strumarium</I> stem extract on melanin synthesis. It inhibited melanin synthesis in a concentration-dependent manner, but it did not directly inhibit tyrosinase, the rate-limiting melanogenic enzyme, and instead downregulated microphthalmia-associated transcription factor (MITF) and tyrosinase expression. MITF, the master regulator of pigmentation, is a target of the Wnt signaling pathway, which includes glycogen synthase kinase 3β (GSK3β) and β-catenin. Hence, the influence of <I>X. strumarium</I> stem extract on GSK3β and β-catenin was further investigated. <I>X. strumarium</I> induced GSK3β phosphorylation (inactivation), but the level of β-catenin did not change. Moreover, a specific GSK3β inhibitor restored <I>X. strumarium</I>-induced melanin reduction. Hence, we suggest that <I>X. strumarium</I> inhibits melanin synthesis through downregulation of tyrosinase <I>via</I> GSK3β phosphorylation.
著者
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Min Young
Department Of Internal Medicine University Of Ulsan College Of Medicine Asan Medical Center
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Park Kyoung-chan
Department Of Dermatology Seoul National University Bundang Hospital
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Kim Dong-seok
Department Of Dermatology Seoul National University Bundang Hospital
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Park Kyoung-chan
Department Of Dermatology Seoul National University College Of Medicine
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LI Hailan
Department of Biochemistry, Chung-Ang University College of Medicine
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