Change in Mutagenic Activity of Genistein after a Nitrite Treatment
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概要
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This study examined the mutagenic activity of genistein after a nitrite treatment under acidic conditions. Nitrite-treated genistein exhibited mutagenic activity toward Salmonella typhimurium strains TA 100 and TA 98 with or without S9 mix. Nitrite-treated genistein was demonstrated by electron spin resonance to generate radicals. An instrumental analysis showed 3'-nitro-genistein to have been formed in the reaction mixture. However, 3'-nitro-genistein did not exhibit mutagenic activity toward the S. typhimurium strains, suggesting that other mutagens might also have been formed in the reaction mixture. The clastogenic properties of nitrite-treated genistein and 3'-nitro-genistein were examined by a micronucleus test with male ICR mice. Nitrite-treated genistein and 3'-nitro-genistein showed a significantly higher frequency of micronucleated reticulocytes in mice than in the control group. These results suggest that a daily oral intake of genistein and nitrite through foodstuffs might induce the formation of various mutagenic compounds in the body.
著者
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Kinae Naohide
School Of Food And Nutritional Science University Of Shizuoka
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Shimamura Yuko
Dep. Of Nutrition And Food Sci. Ochanomizu Univ.
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Kato Tatsuya
School Of Food And Nutritional Sciences Graduate School Of Nutritional And Environmental Sciences And Global Coe Program University Of Shizuoka
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MASUDA Shuichi
School of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Sciences and Global COE Program, University of Shizuoka
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SHIMAMURA Yuko
School of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Sciences and Global COE Program, University of Shizuoka
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Yu-feng Tan
Zhejiang Academy Of Medical Sciences
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Iwamoto Ken-ichi
School Of Pharmaceutical Sciences University Of Shizuoka
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